A myeloproliferative disorder manifested by persistent basophilia, granulocytic leukemia, and erythroleukemig phases

Myeloproliferative disorder of rats induced by myeloproliferative sarcoma virus.

The pathogenesis of myeloproliferative disorder remains unknown, but there have been some experiments on murine myeloproliferative sarcoma induced by certain viruses. Myeloproliferative sarcoma virus which is well known among such viruses, causes myeloproliferative disorder in mice and today's work will reveal tumorigenicity of this virus in rats. Two groups of Jar-2 rats (31 young rats and 28 ...

Myelofibrosis in chronic granulocytic leukemia.

In 181 patients with chronic granuloMF with CCL was associated with three cytic leukemia (CGL) 39 patients demonfindings: (1) elevation of the leukocyte strated myelofibrosis (MF) during the alkaline phosphatase, (2) a very poor course of their disease. These groups prognosis and (3) the frequent associacan be divided into two groups: one tion of MF and blastic transformation of group initially...

Chronic granulocytic leukemia and the Philadelphia chromosome.

Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome.

Cytogenetic, immunologic, and electron microscopic studies were performed on the blast cells of 28 pediatric patients with Down's syndrome, 13 with acute leukemia (DS-AL) and 15 with transient myeloproliferative disorders (DS-TMD). Clonal chromosome abnormalities were found in the cells of all patients with DS-AL but not those with DS-TMD. The younger ages and higher hemoglobin concentrations, ...

Chronic myelogenous leukemia and myeloproliferative disease.

In Section I, Dr. Stephen O'Brien reviews the latest data on the clinical use of imatinib (STI571, Gleevec, Glivec) in CML. His review focuses on the use of imatinib in newly diagnosed chronic phase patients and summarizes cytogenetic and molecular response data, as well as use of the agent at high doses and in combination with other drugs. A brief summary of the prospective international Phase...